| 1 | Camilo - Ropa Cara (Official Video) | CamiloVEVO | 156,078,671 | 2,611,826 | 319,787 | 154,634 | 2021-01-18 |
| 2 | Ricardo Montaner, Mau y Ricky, Camilo, Evaluna Montaner - Amén | RicardoMontanerVEVO | 135,180,305 | 2,053,096 | 63,635 | 78,051 | 2020-12-23 |
| 3 | Daddy Yankee & Marc Anthony - De Vuelta Pa' La Vuelta (Video Oficial) | Daddy Yankee | 106,843,000 | 1,102,385 | 29,954 | 37,436 | 2020-12-11 |
| 4 | Ed Sheeran - Afterglow [Official Performance Video] | Ed Sheeran | 69,351,787 | 943,150 | 14,019 | 38,387 | 2020-12-21 |
| 5 | Selena Gomez - De Una Vez (Official Video) | SelenaGomezVEVO | 66,273,912 | 2,871,237 | 55,236 | 246,225 | 2021-01-15 |
| 6 | Taylor Swift - willow (Official Music Video) | TaylorSwiftVEVO | 64,223,910 | 1,638,421 | 31,630 | 104,338 | 2020-12-11 |
| 7 | Selena Gomez, Rauw Alejandro - Baila Conmigo (Official Video) | SelenaGomezVEVO | 63,494,140 | 1,880,148 | 37,306 | 126,375 | 2021-01-29 |
| 8 | Ozuna x J Balvin x Chencho Corleone - Una Locura (Video Oficial) | Ozuna | 62,471,308 | 467,953 | 12,509 | 12,295 | 2020-12-18 |
| 9 | @Anuel AA & Ozuna - ANTES (Video Oficial) | Ozuna | 42,301,718 | 423,286 | 12,702 | 21,544 | 2021-01-22 |
| 10 | Ariana Grande - 34+35 Remix (feat. Doja Cat and Megan Thee Stallion) (Official Video) | ArianaGrandeVevo | 41,602,293 | 1,902,770 | 48,650 | 104,261 | 2021-02-12 |
| 11 | @Anuel AA & Ozuna - LA MARIA | Ozuna | 32,567,791 | 359,485 | 10,622 | 9,985 | 2021-01-22 |
| 12 | @Anuel AA & Ozuna - RD | Ozuna | 30,201,806 | 320,732 | 5,325 | 14,536 | 2021-01-22 |
| 13 | Daddy Yankee - Problema (Video Oficial) | Daddy Yankee | 25,329,509 | 750,143 | 30,166 | 50,966 | 2021-02-26 |
| 14 | Camilo, Evaluna Montaner - Machu Picchu (Official Video) | CamiloVEVO | 22,917,188 | 834,651 | 155,937 | 145,483 | 2021-03-01 |
| 15 | Ariana Grande - 34+35 (Remix / Lyric Video) ft. Doja Cat, Megan Thee Stallion | ArianaGrandeVevo | 20,841,126 | 1,176,893 | 18,457 | 72,328 | 2021-01-15 |
| 16 | Justin Bieber - Hold On | JustinBieberVEVO | 18,956,797 | 1,117,758 | 24,153 | 86,667 | 2021-03-05 |
| 17 | Taylor Swift - Love Story (Taylor’s Version) [Official Lyric Video] | TaylorSwiftVEVO | 17,935,989 | 1,168,089 | 9,044 | 92,751 | 2021-02-12 |
| 18 | CNCO - Dejaría Todo (Official Video) | CNCOVEVO | 17,578,423 | 350,034 | 7,617 | 45,628 | 2021-02-05 |
| 19 | ENHYPEN (엔하이픈) 'Let Me In (20 CUBE)' Official MV | Big Hit Labels | 16,525,260 | 1,184,702 | 9,208 | 118,928 | 2020-12-20 |
| 20 | Katy Perry - Not the End of the World | KatyPerryVEVO | 16,095,573 | 520,579 | 17,500 | 52,331 | 2020-12-21 |
| 21 | Luis Fonsi, Rauw Alejandro - Vacío | LuisFonsiVEVO | 15,816,604 | 266,418 | 7,401 | 7,344 | 2021-02-19 |
| 22 | Ozuna - MALA (Video Oficial) | Ozuna | 15,771,877 | 169,341 | 4,378 | 5,154 | 2020-12-25 |
| 23 | Daddy Yankee - 2K20 Live Parte 2 | Daddy Yankee | 15,531,421 | 257,713 | 5,927 | 9,984 | 2020-12-13 |
| 24 | Selena Gomez & Rauw Alejandro - Baila Conmigo (Premio Lo Nuestro 2021) | SelenaGomezVEVO | 14,337,992 | 471,882 | 6,915 | 20,027 | 2021-02-19 |
| 25 | @Anuel AA & Ozuna - NENA BUENA | Ozuna | 14,116,041 | 203,081 | 3,699 | 5,129 | 2021-01-22 |
| 26 | NF - CLOUDS | NFVEVO | 13,744,254 | 733,421 | 8,116 | 78,681 | 2021-02-18 |
| 27 | Taylor Swift - champagne problems (Official Lyric Video) | TaylorSwiftVEVO | 13,069,104 | 308,492 | 3,189 | 13,488 | 2020-12-11 |
| 28 | Daddy Yankee - CORONA | Freestyle (Video Oficial) | Daddy Yankee | 12,909,302 | 585,788 | 10,800 | 27,623 | 2020-12-25 |
| 29 | [2021NYEL] 'Dynamite' - BTS (방탄소년단) | Big Hit Labels | 12,480,830 | 843,554 | 5,702 | 30,732 | 2021-01-04 |
| 30 | Luis Fonsi, Zé Neto & Cristiano, Thyy - Por Isso Que Eu Bebo | LuisFonsiVEVO | 11,225,935 | 87,846 | 2,236 | 4,160 | 2021-02-05 |
| 31 | Selena Gomez, Rauw Alejandro - Baila Conmigo (Performance Video) | SelenaGomezVEVO | 11,187,547 | 328,863 | 3,893 | 11,973 | 2021-02-24 |
| 32 | @Anuel AA & Ozuna - PERFECTO | Ozuna | 10,833,897 | 226,179 | 3,701 | 6,786 | 2021-01-22 |
| 33 | Ed Sheeran - Afterglow [Official Lyric Video] | Ed Sheeran | 10,746,375 | 240,069 | 2,084 | 7,007 | 2020-12-26 |
| 34 | @Anuel AA & Ozuna - NUNCA | Ozuna | 10,555,714 | 259,659 | 3,805 | 6,615 | 2021-01-22 |
| 35 | Daddy Yankee - 2K20 Live Parte 3 | Daddy Yankee | 10,464,719 | 148,780 | 3,315 | 6,292 | 2020-12-25 |
| 36 | Cali Y El Dandee, Beret - Primera Carta | CaliyElDandeeVEVO | 9,987,426 | 173,739 | 2,141 | 3,485 | 2021-01-21 |
| 37 | J. Balvin - Ma' G | jbalvinVEVO | 9,761,722 | 296,060 | 10,665 | 12,967 | 2021-02-28 |
| 38 | Anuel AA & Ozuna - Los Dioses El Documental | Ozuna | 9,657,880 | 259,532 | 5,073 | 11,706 | 2021-01-20 |
| 39 | @Anuel AA & Ozuna - 100 | Ozuna | 9,598,894 | 190,706 | 3,566 | 4,783 | 2021-01-22 |
| 40 | @Anuel AA & Ozuna - PERREO | Ozuna | 9,226,126 | 206,672 | 4,422 | 6,550 | 2021-01-22 |
| 41 | Taylor Swift - evermore (Official Lyric Video) ft. Bon Iver | TaylorSwiftVEVO | 8,958,473 | 262,039 | 2,377 | 10,165 | 2020-12-11 |
| 42 | C. Tangana, Toquinho - Comerte Entera (Video Oficial) | CTanganaVEVO | 8,770,917 | 120,600 | 6,466 | 4,674 | 2021-01-14 |
| 43 | Camilo, Los Dos Carnales - Tuyo y Mío (Official Video) | CamiloVEVO | 8,562,883 | 322,560 | 11,700 | 11,885 | 2021-03-05 |
| 44 | Julio Peña, Isabela Souza - Vale, vale (De "BIA: Un mundo al revés") | DisneyMusicLAVEVO | 7,654,465 | 149,841 | 5,437 | 31,595 | 2021-01-08 |
| 45 | C. Tangana, Ed Maverick - Párteme La Cara | CTanganaVEVO | 7,567,856 | 108,900 | 4,062 | 3,237 | 2021-02-25 |
| 46 | Camilo - Millones | CamiloVEVO | 6,965,407 | 307,530 | 7,178 | 11,374 | 2021-03-04 |
| 47 | Alejandro Fernández, Christian Nodal - Duele | AFernandezVEVO | 6,707,823 | 98,152 | 2,620 | 2,347 | 2021-02-12 |
| 48 | Ricardo Montaner, Camilo, Mau y Ricky, Evaluna Montaner - Amén (Acústico) | RicardoMontanerVEVO | 6,585,280 | 187,883 | 2,995 | 5,998 | 2021-02-19 |
| 49 | @Anuel AA & Ozuna - CONTRA EL MUNDO | Ozuna | 6,470,605 | 168,120 | 3,146 | 4,204 | 2021-01-22 |
| 50 | Taylor Swift - gold rush (Official Lyric Video) | TaylorSwiftVEVO | 6,352,343 | 172,118 | 1,071 | 7,156 | 2020-12-11 |